The inbox is an input, not a destination
A sequence that only sends will keep chasing someone who already answered — the most expensive mistake in outbound, because it converts an interested reply into an annoyed one. Reading the mailbox back over IMAP and halting the sequence on a detected reply makes the system aware of the conversation it started.
Verify: The reply detector scans configured mailboxes, matches replies against campaign logs, and marks those leads so the follow-up scheduler skips them.